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Diagnostic sub-classification of non-small cell lung cancer: Importance in clinical therapeutics and prognostication

M. J. Donovan, A. Kotsianti, A. Colomer, M. Verdú, M. Clayton, H. Pang, S. Hamann, C. Cordón-Cardó, X. Puig.

Background: The association of EGFR mutations with bronchoalveolar carcinoma (BAC) / non-small cell lung cancer (NSCLC) and the therapeutic and prognostic variability reported for lung cancer has reinforced the need for more accurate NSCLC sub-classification. The present […]


Genetic and immunophenotype analyses of TP53 in bladder cancer: TP53 alterations are associated with tumor progression

Erill N1, Colomer A1, Verdú M2, Román R1, Condom E1, Hannaoui N3, Banús JM3, Cordón-Cardó C4, and Puig X 1,2.

1BIOPAT, Grup Assistència, Barcelona; 2HISTOPAT Laboratoris, Barcelona; 3ICUN, Barcelona; and 4Division of Molecular Pathology, Memorial Sloan-Kettering Cancer Center, New York.

Altered p53 status is a frequent event in bladder cancer and reported to have prognostic significance. We […]


MSI status modulates the value of some molecular markers in colorectal tumors

A. Colomer, N. Erill, M. Verdú, R. Román, A Vidal, X. Puig.

BIOPAT. Biopatologia Molecular, SL. Barcelona, Spain.

LOH 17p/TP53 and LOH 18q/DCC have been related to prognosis of colorectal adenocarcinomas. Since MSI-H tumors have a minor rate of TP53 mutations and rarely present allelic deletions, we intended to study these molecular features in a series of 197 […]


TP53, 17P and 18Q alterations as prognostic markers in MSS colorectal adenocarcinomas

Anna Colomer1, Nadina Erill1, Montse Verdú2, Ruth Román1, August Vidal1,2, Xavier Puig1,2.

1BIOPAT, Biopatologia Molecular, Barcelona, Spain. 2Histopat Laboratoris, Barcelona, Spain.

Two different patterns have been described for colorectal tumorigenesis. The main one -affecting 85% of sporadic tumors- is based on the familial adenomatous polyposis (FAP) model, a multistep process that involves at least APC, K-RASDCC andTP53 genes. […]


Marcadores de pronóstico en el carcinoma de mama

M. Guix Pericas 1,2, C. Cordón Cardó 1,2,3, M. A. Cañadas Bouzas 1, A. Colomer Valero 2,  X. Puig Torrus 1,2.

1HISTOPAT S.A. Laboratoris. 2BIOPAT. Biopatologia molecular S.L. Grup Assistència. Barcelona. 3Memorial Sloan Kettering Cancer Center. Division of Molecular Pathology. Nueva York.


El carcinoma de mama es una de las neoplasias malignas más frecuentes y una de […]